ATLASrift - a Virtual Reality application

We present ATLASrift - a Virtual Reality application that provides an interactive, immersive visit to ATLAS experiment. We envision it being used in two different ways: first as an educational and outreach tool - for schools, universities, museums and interested individuals, and secondly as an event viewer for ATLAS physicists - for them it will provide a much better spatial awareness of an event, track and jet directions, occupancies and interactions with detector structures. Using it, one can learn about the experiment as a whole, visit individual sub-detectors, view real interactions, or take a scripted walkthrough explaining questions physicists are trying to answer. We briefly describe our platform of choice - OculusRift VR system, the development environment - UnrealEngine, and, in detail, the numerous technically demanding requirements that had to be fulfilled in order to provide a comfortable user experience. Plans for future versions include making the experience social by adding multi-user/virtual presence options, event animation, interactive virtual demonstrations of key high energy physics concepts, or detector operating principles.Comment: Presentation at the DPF 2015 Meeting of the American Physical Society Division of Particles and Fields, Ann Arbor, Michigan, August 4-8, 201

Oral Bacterial Microbiota in Digestive Cancer Patients: A Systematic Review

The relation between the gut microbiota and human health is increasingly recognized. Recently, some evidence suggested that dysbiosis of the oral microbiota may be involved in the development of digestive cancers. A systematic review was conducted according to the PRISMA guidelines to investigate the association between the oral microbiota and digestive cancers. Several databases including Medline, Scopus, and Embase were searched by three independent reviewers, without date restriction. Over a total of 1654 records initially identified, 28 studies (2 prospective cohort studies and 26 case-controls) were selected. They investigated oral microbiota composition in patients with esophageal squamous cell carcinoma (n = 5), gastric cancer (n = 5), colorectal cancer (n = 9), liver carcinoma (n = 2), and pancreatic cancer (n = 7). In most of the studies, oral microbiota composition was found to be different between digestive cancer patients and controls. Particularly, oral microbiota dysbiosis and specific bacteria, such as Fusobacterium nucleatum and Porphyromonas gingivalis, appeared to be associated with colorectal cancers. Current evidence suggests that differences exist in oral microbiota composition between patients with and without digestive cancers. Further studies are required to investigate and validate oral–gut microbial transmission patterns and their role in digestive cancer carcinogenesis

Influence of Irradiance, Flow Rate, Reactor Geometry, and Photopromoter Concentration in Mineralization Kinetics of Methane in Air and in Aqueous Solutions by Photocatalytic Membranes Immobilizing Titanium Dioxide

Photomineralization of methane in air (10.0–1000 ppm (mass/volume) of C) at100%relative humidity (dioxygen as oxygen donor) was systematically studied at318±3 K in an annular laboratory-scale reactor by photocatalytic membranes immobilizing titanium dioxide as a function of substrate concentration, absorbed power per unit length of membrane, reactor geometry, and concentration of a proprietary vanadium alkoxide as photopromoter. Kinetics of both substrate disappearance, to yield intermediates, and total organic carbon (TOC) disappearance, to yield carbon dioxide, were followed. At a fixed value of irradiance (0.30 W⋅cm-1), the mineralization experiments in gaseous phase were repeated as a function of flow rate (4–400 m3⋅h−1). Moreover, at a standard flow rate of 300 m3⋅h−1, the ratio between the overall reaction volume and the length of the membrane was varied, substantially by varying the volume of reservoir, from and to which circulation of gaseous stream took place. Photomineralization of methane in aqueous solutions was also studied, in the same annular reactor and in the same conditions, but in a concentration range of 0.8–2.0 ppm of C, and by using stoichiometric hydrogen peroxide as an oxygen donor. A kinetic model was employed, from which, by a set of differential equations, four final optimised parameters,k1andK1,k2andK2, were calculated, which is able to fit the whole kinetic profile adequately. The influence of irradiance onk1andk2, as well as of flow rate onK1andK2, is rationalized. The influence of reactor geometry onkvalues is discussed in view of standardization procedures of photocatalytic experiments. Modeling of quantum yields, as a function of substrate concentration and irradiance, as well as of concentration of photopromoter, was carried out very satisfactorily. Kinetics of hydroxyl radicals reacting between themselves, leading to hydrogen peroxide, other than with substrate or intermediates leading to mineralization, were considered, and it is paralleled by a second competition kinetics involving superoxide radical anion

Nonlinear Modelling of Kinetic Data Obtained from Photocatalytic Mineralisation of 2,4-Dichlorophenol on a Titanium Dioxide Membrane

Photomineralisation of 2,4-dichlorophenol (DCP) in aqueous solutions (10.0–100.0 mg/L of C) was systematically studied at 318±3 K, in an annular laboratory-scale reactor, by photocatalytic membranes immobilizing titanium dioxide, as a function of substrate concentration, and absorbed power per unit length of membrane. Kinetics of both substrate disappearance, to yield intermediates, and total organic carbon (TOC) disappearance, to yield carbon dioxide, were followed (first series of experiments). At a fixed value of irradiance (1.50 W⋅cm−1), other series of mineralization experiments were repeated (second series of experiments) by carrying out only analyses of chemical oxygen demand (COD), in order to compare modelling results of the two sets of experiments. In both sets of experiments, stoichiometric hydrogen peroxide was used as oxygen donor. For the first series of experiments, a kinetic model was employed, already validated in previous work, from which, by a set of differential equations, four final optimised parameters, k1 and K1, k2 and K2, were calculated. By these parameters, the whole kinetic profile could be fitted adequately. The influence of irradiance on k1 and k2 could be rationalised very well by this four-parameter kinetic model. Modelling of quantum yields, as a function of irradiance, could also be carried out satisfactorily. As has been found previously for other kinds of substrates, modelling of quantum yields for DCP mineralization is consistent with kinetics of hydroxyl radicals reacting between themselves, leading to hydrogen peroxide, other than with substrate or intermediates leading finally to carbon dioxide, paralleled by a second competition kinetics involving superoxide radical anion. For the second series of experiments, on the contrary, the Langmuir-Hinshelwood model was employed. Uncertainties of COD analyses, coupled with discrepancies of this model and with its inability to reproduce kinetics up to complete mineralization, are underlined

Examining the Relationship of Clinical and Laboratory Parameters With Infectiousness to Phlebotomus perniciosus and Its Potential Infectivity in Dogs With Overt Clinical Leishmaniasis

Infected dogs are considered the main domestic animal reservoirs for Leishmania infantum parasite. Infectiousness to competent phlebotomine vectors has been associated with many factors, the main being the severity of the disease exhibited by infected dogs. This study examines the relationship between different clinical parameters and the infectiousness to colonized Phlebotomus perniciosus sand flies having a blood meal on dogs. Data obtained in the present study come from an untreated group of Leishmania sick dogs submitted to xenodiagnosis for the evaluation of a spot on insecticide solution. Seventeen dogs were diagnosed as affected by leishmaniasis through clinical examination, immunofluorescence antibody test (IFAT) serology, and loop-mediated isothermal amplification (LAMP). The disease severity (clinical score) was staged by using a numeric value derived from eight clinical and parasitological parameters. Xenodiagnosis was performed on caged dogs exposed for 1.5 h to sand-fly bites. The following parameters related to sand flies were examined: blood feeding (% of blood engorged females), promastigote detection (% of promastigote-positive sand flies), promastigote burden, and the promastigote stage maturation (potential transmissibility rate). Statistical relationship between the clinical score and entomological parameters was investigated, as well as the possible correlation between each clinical and laboratory parameters and sand fly infection/infectivity. The severity of clinical score may influence the blood feeding by, and the probability of promastigote detection in, sand flies; skin lesions seem to be the main factor that influences the rate of blood feeding. Promastigote burden is related to IFAT titer, skin lesions, and clinical score. All entomological parameters are strongly related among them. This study confirms that both P. perniciosus infection and infectivity are influenced by a dog’s clinical condition

Preliminary investigation on tick fauna in the neighborhood of Tarquinia, Lazio, Italy

Introduction. This study represents a preliminary inquiry on tick fauna composition carriedout in Maremma, Central Italy, where very few data are available.Materials and methods. The study area was selected in the limestone hills surroundingTarquinia town, on the base of suitable elements directly affecting the tick occurrenceand the possible circulation of tick-borne pathogens, such as wild cattle rearing, kind ofvegetation and human activities. Since a proper understanding of tick ecology is criticalin predicting the risk of tick-borne pathogen transmission in a given area, a series of surveyswas planned in such area in 2011.Results. One hundred fifty-four ticks belonging to 4 genera and 6 species, namely Ixodesricinus (n. = 109; 70%), Rhipicephalus bursa (n. = 18; 12%), Rhipicephalus turanicus (n. =14; 9%), Rhipicephalus sanguineus (n. = 6; 4%), Hyalomma marginatum (n. = 4; 3%) andDermacentor marginatus (n. = 3; 2%) were identified and reported for the area.Discussion. The results of this acarological research represent a significant contributionto the knowledge of the tick fauna of rural areas in Northern Lazio Region, as first steptoward a future molecular investigation on pathogen circulation. 

Brain Circuitry Supporting Multi-Organ Autonomic Outflow in Response to Nausea

While autonomic outflow is an important co-factor of nausea physiology, central control of this outflow is poorly understood.We evaluated sympathetic (skin conductance level) and cardiovagal (high-frequency heart rate variability) modulation, collected synchronously with functional MRI (fMRI) data during nauseogenic visual stimulation aimed to induce vection in susceptible individuals. Autonomic data guided analysis of neuroimaging data, using a stimulus-based (analysis windows set by visual stimulation protocol) and percept-based (windows set by subjects’ ratings) approach. Increased sympathetic and decreased parasympathetic modulation was associated with robust and anti-correlated brain activity in response to nausea. Specifically, greater autonomic response was associated with reduced fMRI signal in brain regions such as the insula, suggesting an inhibitory relationship with premotor brainstem nuclei. Interestingly, some sympathetic/parasympathetic specificity was noted. Activity in default mode network and visual motion areas was anti-correlated with parasympathetic outflow at peak nausea. In contrast, lateral prefrontal cortical activity was anticorrelated with sympathetic outflow during recovery, soon after cessation of nauseogenic stimulation. These results suggest divergent central autonomic control for sympathetic and parasympathetic response to nausea. Autonomic outflow and the central autonomic network underlying ANS response to nausea may be an important determinant of overall nausea intensity and, ultimately, a potential therapeutic target

Home-based pulmonary rehabilitation in patients undergoing (chemo)radiation therapy for unresectable lung cancer: a prospective explorative study

Aims The prevention of pulmonary toxicity is an important goal for patient candidate to radiation therapy for lung cancer. There is a lack of evidence on the role of exercise training for patients with unresectable stage III lung cancer candidated to radical treatment. The aim of this study was to evaluate the feasibility of a home-based pulmonary rehabilitation (PR) program and to identify reliable tools in terms of respiratory function, exercise capacity and quality of life. Methods Patients' recruitment lasted from April 2020 till February 2022. The PR program was proposed concomitantly to radiation therapy to the first 20 patients (interventional group, IG), and the other 20 patients were identified as an observational group (OG). All patients were assessed at baseline (T0) and after 8 weeks (T2) with 6 minute walking test (6MWT), modified Borg Scale (mBORG), SF-36 questionnaire (SF-36) and pulmonary function test (PFT); after 4 weeks (T1), only SF-36 was administered. Results A decrease of 13.8 m in the walked-distance was registered in the OG between T0 and T2 (p = 0.083). Instead, an increase of 56.6 m in the distance walked was recorded in the IG between T0 and T2 (p <= 0.001). In the OG, the mBORG scores showed a negative trend. On the contrary, in the IG, these scores showed a slight improvement. In the OG, all the items of SF-36 scores decreased between T0 and T1. In the IG, an increased trend from T0 to T2 was observed for all the items of SF-36. No clinically significant variations were detected from baseline to T2 in both groups regarding PFT. Conclusion The 6MWT, mBORG and SF-36 resulted as useful tools to assess the role of a PR program. A significant gain in functional exercise capacity and a prevention of the physiological impairment of QoL during radio(chemo)therapy was registered

Nodal-Stage Classification in Invasive Lobular Breast Carcinoma: Influence of Different Interpretations of the pTNM Classification

Purpose Application of current nodal status classification is complicated in lobular breast carcinoma metastases. The aim of this study was to define the optimal interpretation of the pTNM classification in sentinel node (SN) -positive patients to select patients with limited or with a high risk of non-SN involvement. Patients and Methods SN metastases of 392 patients with lobular breast carcinoma were reclassified according to interpretations of the European Working Group for Breast Screening Pathology (EWGBSP) and guidelines by Turner et al, and the predictive power for non-SN involvement was assessed. Results Reclassification according to definitions of EWGBSP and Turner et al resulted in different pN classification in 73 patients (19%). The rate of non-SN involvement in the 40 patients with isolated tumor cells according to Turner et al and with micrometastases according to EWGBSP was 20%, which is comparable to the established rate for micrometastases. The rate of non-SN involvement in the 29 patients with micrometastases according to Turner et al and with macrometastases according to EWGBSP was 48%, which is comparable to the established rate for macrometastases. Therefore, the EWGBSP method to classify SN tumor load better reflected the risk of non-SN involvement than the Turner et al system. Conclusion Compared with the guidelines by Turner et al, the EWGBSP definitions better reflect SN metastatic tumor load and allow better differentiation between patients with lobular breast carcinoma who have a limited or a high risk of non-SN metastases. Therefore, we suggest using the EWGBSP definitions in these patients to select high-risk patients who may benefit from additional local and/or systemic therapy

Laboratory-scale photomineralization of n

Kinetics of photocatalytic oxidation of methane, ethane, and n-heptane, to yield intermediates, and photomineralization of intermediates, to yield carbon dioxide and water, was studied in the gaseous phase, at 308±2 K, by a laboratory-scale photoreactor and photocatalytic membranes immobilizing 30±3 wt.% of TiO2, in the presence of aerosolized stoichiometric hydrogen peroxide as oxygen donor, and at a relative humidity close to 100%. The whole volume of irradiated solution was 4.000±0.005 L, the ratio between this volume and the geometrical apparent surface of the irradiated side of the photocatalytic membrane was 3.8±0.1 cm, and the absorbed power was 0.30 W/cm (cylindrical geometry). The pinetic parameters of the present work substantially coincide with those of the same molecules previously studied in aqueous solution, within the limits of experimental uncertainty. Photocatalytic processes thus appear to be controlled by interface phenomena, which are ruled kinetically, and apparently also thermodynamically, by concentration gradients, independently on diffusion and other processes in the aqueous or gaseous bulk, if turbulence in these phases is adequately assured